Both Notch signaling and proteasome pathway are involved in regulating CD105 expression in hUC-MSCs.

Abstract

<p>Flow cytometry assay shows that 0.25–1 μM GSI-I do not induce changes in expression of CD73, CD90 and CD105 (A), but 5–10nM Bortezomib significantly inhibits the expression of CD105, but not CD73 and CD90 (B); Moreover, while the siNotch1 transfection alone has no effect on expression of surface markers, it further increases the inhibitory effect of 10 nM Bortezomib on CD105, slightly on CD90, but not on CD73 (C). The * indicates the statistical significance with <i>p</i><0.05.</p