<i>Lactobacillus acidophilus</i> improved the contractile activity of intestinal smooth muscle impaired by TBI.

Abstract

<p>Ninety C57BL/6 mice were randomly divided into three groups including control, TBI and TBI + <i>Lactobacillus acidophilus</i> groups. The interaction of <i>Lactobacillus acidophilus</i> and time on intestinal contractile activity was not significant. (A) The contractile activity was determined by histologic and physiologic analyses. (B) The average contractile amplitude was decreased after TBI, **<i>P</i> < 0.01 compared with control. <i>Lactobacillus acidophilus</i> could increase in contractile amplitude, #<i>P</i> < 0.05 compared with TBI. (C and D) The contractile frequency and tension were also decreased after TBI, **<i>P</i> < 0.01 compared with control. <i>Lactobacillus acidophilus</i> significantly attenuated TBI-mediated decreases of contractile frequency and tension, #<i>P</i> < 0.05 compared with TBI. (E) The intestinal transit rate was decreased after TBI, **<i>P</i> < 0.01 compared with control. <i>Lactobacillus acidophilus</i> significantly attenuated TBI-mediated decrease of intestinal transit rate, ##<i>P</i> < 0.01 compared with TBI.</p