Repository landing page

We are not able to resolve this OAI Identifier to the repository landing page. If you are the repository manager for this record, please head to the Dashboard and adjust the settings.

Cocaine- and nicotine-induced nucleosome repositioning comparisons.


<p>(A) Changes in nucleosome repositioning that were unique to nicotine or cocaine, and common to both the drugs. (B-E) Nucleosome repositioning in response to nicotine or cocaine exposure is shown. (B) Nucleosome repositioning upstream of TSS, at the TSS and at the beginning of the coding sequence in the <i>CDNK1C</i> gene around the TSS was induced by nicotine and not by cocaine (nicotine-specific). Nicotine exposure positioned nucleosomes upstream of the TSS, depleted the nucleosomes at the TSS, and positioned nucleosomes at the start of the coding sequence. On the other hand, cocaine exposure for 20 min, did not produce changes in nucleosome position compared to the drug naïve state. (C) Nicotine and cocaine both induced nucleosome repositioning upstream of TSS, at the TSS and at the beginning of the coding sequence in the <i>ANGPT2</i> gene. However, 60 min cocaine-specific changes were detected at the +1 nucleosome (asterisk), just downstream of the <i>ANGPT2</i> TSS. The 60 min nicotine-induced nucleosome repositioning at <i>ANGPT2</i> is similar to the 20 min time point and therefore is not shown. (D) Changes common to nicotine (10 min) and cocaine (20 min) just upstream and downstream of the TSS of <i>FNB2</i> gene. (E) Neither nicotine (10 min) nor cocaine (20 min) produced nucleosome repositioning across the promoter and 5’ region of <i>BMP3</i>. Nucleosome positions relative to the TSS and coding sequence of each gene in the drug naïve (black) and drug exposed (red) states are further illustrated pictorially at the bottom of the figure. Each sphere (black or red) represents a nucleosome.</p

Similar works

Full text



Last time updated on 12/02/2018

This paper was published in FigShare.

Having an issue?

Is data on this page outdated, violates copyrights or anything else? Report the problem now and we will take corresponding actions after reviewing your request.