Clustergram of Top Enriched Pathway, TF, and GO terms.

Abstract

<p>Concatenated enrichment profiles for GO, C2, and TF gene set collections, similar to <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0143563#pone.0143563.g003" target="_blank">Fig 3</a>, ordered by hierarchical clustering of Euclidean distance between rows. Rows have been normalized by dividing by the row sum for visualization, intensity is proportional to normalized enrichment. Heatmap is partitioned into groups A-E based on hierarchical clustering. Clusters A, B, and C are primarily involved in the immune response and are enriched in gene subsets that include more genes. Clusters D and E are predominantly related to developmental and transcriptional regulation processes.</p