Detailed GO enrichment.

Abstract

<p>Top 25 enriched GO categories across all three GO namespaces identified by topGO for different numbers of DE genes. X-axis indicates the number of top genes used for the enrichment in each GO category, e.g. the first column uses the top 25 genes, the second column uses the top 50, and so on. The intensity is proportional to–log10(p-value) from topGO. White dots indicate the gene set with the most significant p-value, concordant with <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0143563#pone.0143563.t005" target="_blank">Table 5</a>. This figure shows that the first three GO Categories are defined by genes that are among the top 25 to 150 DE genes in the dataset. GO Categories further down the list are defined by genes whose differential expression is less pronounced between HD and controls.</p