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Induction of Stemlike Cells with Fibrogenic Properties by Carbon Nanotubes and Its Role in Fibrogenesis
Abstract
We developed a three-dimensional fibroblastic nodule model for fibrogenicity testing of nanomaterials and investigated the role of fibroblast stemlike cells (FSCs) in the fibrogenic process. We showed that carbon nanotubes (CNTs) induced fibroblastic nodule formation in primary human lung fibroblast cultures resembling the fibroblastic foci in clinical fibrosis and promoted FSCs that are highly fibrogenic and a potential driving force of fibrogenesis. This study provides a predictive 3D model and mechanistic insight on CNT fibrogenesis- Dataset
- Media
- Biophysics
- Medicine
- Cell Biology
- Genetics
- Ecology
- Developmental Biology
- Hematology
- Biological Sciences not elsewhere classified
- FSC
- fibroblastic foci
- fibrogenic process
- Fibrogenic Properties
- Carbon Nanotubes
- 3 D model
- Stemlike Cells
- fibroblast stemlike cells
- fibroblastic nodule formation
- carbon nanotubes
- fibrogenicity testing
- fibroblastic nodule model
- lung fibroblast cultures
- CNT fibrogenesis
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Last time updated on 12/02/2018
This paper was published in The Francis Crick Institute.
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