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Yb(OTf)<sub>3</sub>‑Mediated Access to Furans from β‑Ketothioamides via Eschenmoser Sulfide Contraction Reaction
Abstract
A mild and straightforward synthetic protocol for construction of a furan skeleton promoted by Yb(OTf)<sub>3</sub> from β-ketothioamides and arylglyoxals has been developed at room temperature. Importantly, this protocol involves a tandem sequence that includes aldol condensation, N-cyclization, ring opening, O-cyclization, S-cyclization, and Eschenmoser sulfide contraction- Dataset
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- aldol condensation
- Access
- Yb
- Eschenmoser Sulfide Contraction ReactionA
- room temperature
- Importantly
- furan skeleton
- Furan
- Ketothioamide
- tandem sequence
- arylglyoxal
- ketothioamide
- construction
- ring opening
- Eschenmoser sulfide contraction
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Last time updated on 12/02/2018
This paper was published in The Francis Crick Institute.
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