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textjournal article
oaioai:figshare.com:article/2369017

Tensile Mechanics of α‑Helical Polypeptides

Authors
Publication date
18 February 2016
Publisher
Doi

    Abstract

    We have developed a statistical mechanical model of the force–extension behavior of α-helical polypeptides, by coupling a random-coil polypeptide elastic model of an inhomogeneous partially freely rotating chain, with the latest version of the helix–coil transition model AGADIR. The model is capable of making quantitatively accurate predictions of force–extension behavior of a given polypeptide sequence including its dependence on pH, temperature and ionic strength. This makes the model a valuable tool for single-molecule protein unfolding experimental studies. Our model predicts the highly reversible unraveling of α-helical structures at small forces of about 20 pN, in good agreement with recent experimental studies

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    The Francis Crick Institute

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    Last time updated on 12/02/2018

    This paper was published in The Francis Crick Institute.

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