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Asymmetric Synthesis of Cyclobutanones: Synthesis of Cyclobut-G

Abstract

A simple, efficient, and stereoselective approach has been developed for obtaining chiral cis- and trans-disubstituted cyclobutanones from readily available alkyl- and functionalized alkyl-substituted enol ethers. The usefulness of these cyclobutanones is illustrated by an enantioselective synthesis of cyclobut-G (Lobucavir)

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Last time updated on 12/02/2018

This paper was published in FigShare.

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