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K<sub>D</sub> determination of SMAC-rhodamine binding to BIR2 and BIR3 domains of cIAP1 and cIAP2.
Abstract
<p>Data were for assay conditions consisting of 25 mM Hepes @ 7.5, 1 mM TCEP, 20 nM SMAC-rhodamine with varying concentrations of various BIR domains. For cIAP1-BIR3, assays included 40 mM β-glycerol phosphate. Plates were read on the Analyst and observed mP were plotted against the log of protein concentration.</p- Image
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- Biophysics
- Biochemistry
- Cell Biology
- Genetics
- Molecular Biology
- Pharmacology
- Biotechnology
- Evolutionary Biology
- Immunology
- Cancer
- Hematology
- Infectious Diseases
- Biological Sciences not elsewhere classified
- Chemical Sciences not elsewhere classified
- cIAP 1 protein levels
- IAP family members cIAP 1
- SAR
- structure activity relationship
- NF -κB activation
- cIAP 1
- Sensitize Cancer Cells
- cIAP 2
- novel anticancer drugs
- support cell survival
- fluorochrome-conjugated SMAC peptides
- cIAP 2 BIR 3 binding activity
- Potent SMAC Mimetics
- RIP 1 binding
- tumor cell line
- FP
- XIAP
- TNF Family-Induced Apoptosis Members
- IAP family members
- tumor necrosis factor
- tumor cell resistance
- LT
- TNF receptor complexes
- SMAC mimetics
- BIR 3 domains
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Last time updated on 12/02/2018
This paper was published in The Francis Crick Institute.
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