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Base-Promoted Synthesis of <i>N</i>‑Substituted 1,2,3-Triazoles via Enaminone–Azide Cycloaddition Involving Regitz Diazo Transfer

Abstract

The domino reactions between NH-based secondary enaminones and tosyl azide have been developed for the synthesis of various <i>N</i>-substituted 1,2,3-triazoles by employing <i>t</i>-BuONa as the base promoter. Through a key Regitz diazo-transfer process with tosyl azide, the reactions proceed efficiently at room temperature with good substrate tolerance

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The Francis Crick Institute

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Last time updated on 12/02/2018

This paper was published in The Francis Crick Institute.

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