Repository landing page
Nickel-Catalyzed Cross-Coupling of Allyl Alcohols with Aryl- or Alkenylzinc Reagents
Abstract
Nickel-catalyzed cross-coupling of allyl alcohols with aryl- and alkenylzinc chlorides through C–O bond cleavage was performed. Reaction of (<i>E</i>)-3-phenylprop-2-en-1-ol and 1-aryl-prop-2-en-1-ols with aryl- or alkenylzinc chlorides gave linear cross-coupling products. Reaction of 1-phenyl- or 1-methyl-substituted (<i>E</i>)-3-phenylprop-2-en-1-ol with aryl- or alkenylzinc chlorides resulted in 3-aryl/alkenyl-substituted (<i>E</i>)-(prop-1-ene-1,3-diyl)dibenzenes or 3-aryl/alkenyl-substituted (<i>E</i>)-(but-1-enyl)benzene. Reaction of allyl alcohol with <i>p</i>-Me<sub>2</sub>NC<sub>6</sub>H<sub>4</sub>ZnCl resulted in a mixture of normal coupling product 4-allyl-<i>N,N</i>-dimethylaniline and its isomerized product <i>N,N</i>-dimethyl-4-(prop-1-en-1-yl)aniline- Text
- Journal contribution
- Biophysics
- Biochemistry
- Cell Biology
- Molecular Biology
- Pharmacology
- Biotechnology
- Sociology
- Immunology
- Environmental Sciences not elsewhere classified
- Chemical Sciences not elsewhere classified
- Physical Sciences not elsewhere classified
- alkenylzinc chlorides
- 2 NC 6 H 4 ZnCl
- 3-
- phenylprop
- product 4- allyl
- Alkenylzinc Reagents Nickel-catalyzed cross-coupling
- 1- aryl-prop -2-en