Three paired PLS-DA score plot and S-plot reveal altered metabolites following combined therapy with DOX and DZR.

Abstract

<p>The comparative analysis of DD_C and DD_N groups indicates metabolic regulation by DOX + DZR (<b>A</b>), The comparative analysis of DD_C and cancer control groups indicates the metabolic regulation by DOX + DZR in cancerous mice (<b>B</b>), and the comparative analysis of DD_N and normal control groups reveals the unique metabolic effect of DOX and DZR on normal animals.</p