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Surprisingly High Selectivity and High Affinity in Mercury Recognition by H‑Bonded Cavity-Containing Aromatic Foldarands

Abstract

In the absence of macrocyclic ring constraints, few synthetic systems, possessing a mostly solvent-independent well-folded conformation that is predisposed for highly selective and high affinity recognition of metal ions, have been demonstrated. We report here such a unique class of conformationally robust modularly tunable folding molecules termed foldarands that can recognize Hg<sup>2+</sup> ions surprisingly well over 22 other metal ions. Despite the lack of sulfur atoms and having only oxygen-donor atoms in its structure, the best foldarand molecule, i.e., tetramer <b>4</b>, exhibits a selectivity factor of at least 19 in differentiating the most tightly bound Hg<sup>2+</sup> ion from all other metal ions, and a binding capacity that is ≥18 times that of thio-crown ethers. These two noteworthy binding characters make possible low level removal of Hg<sup>2+</sup> ions. With a [<b>4</b>]:[Hg<sup>2+</sup>] molar ratio of 5:1 and a single biphasic solvent extraction, the concentration of Hg<sup>2+</sup> ions could be reduced drastically by 98% (from 200 to 4 ppb) in pure water. <b>4</b> could also effect a highly efficient reduction in mercury content by 98% (from 500 to 10 ppb) in artificial groundwater via multiple successive extractions with an overall consumption of <b>4</b> being 9:1 in terms of [<b>4</b>]:[Hg<sup>2+</sup>] molar ratio

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The Francis Crick Institute

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Last time updated on 12/02/2018

This paper was published in The Francis Crick Institute.

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