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Q-Q plots of the HD Analyses. Figure S7 exhibits the Q-Q plots from the HD analysis adjusting for age at death and RIN from DESeq2 (A), and Classical (B), Bayes (C), and Firth’s (D) Logistic regressions. Each regression method contains three different ways of calculating p-values (Original, DA, and Perm). “Original” p-values (Blue dots) are estimated from asymptotic distribution. “DA” p-values (Black dots) are evaluated from data adaptive asymptotic distribution using 1,000 permutations. “Perm” p-values (Yellow dots) are calculated using 10,000 permutations. (PNG 157 kb
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