Repository landing page

We are not able to resolve this OAI Identifier to the repository landing page. If you are the repository manager for this record, please head to the Dashboard and adjust the settings.

Enantioselective Vinylogous Michael–Michael Cascade Reactions of 3‑Alkylidene Oxindoles and Nitroolefin Enoates

Abstract

A novel bifunctional squaramide catalyzed vinylogous Michael–Michael cascade reaction of 3-alkylidene oxindoles with nitroolefin enoates was developed. This convenient, one-pot cascade reaction serves as a powerful tool for the enantioselective construction of potential bioactive chiral chromans, which have three continuous tertiary stereocenters, in moderate to good yields (up to 85%) with excellent stereoselectivities (up to >19:1 dr and >99% ee)

Similar works

Full text

thumbnail-image

The Francis Crick Institute

redirect
Last time updated on 12/02/2018

This paper was published in The Francis Crick Institute.

Having an issue?

Is data on this page outdated, violates copyrights or anything else? Report the problem now and we will take corresponding actions after reviewing your request.