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Enantioselective Vinylogous Michael–Michael Cascade Reactions of 3‑Alkylidene Oxindoles and Nitroolefin Enoates
Abstract
A novel bifunctional squaramide catalyzed vinylogous Michael–Michael cascade reaction of 3-alkylidene oxindoles with nitroolefin enoates was developed. This convenient, one-pot cascade reaction serves as a powerful tool for the enantioselective construction of potential bioactive chiral chromans, which have three continuous tertiary stereocenters, in moderate to good yields (up to 85%) with excellent stereoselectivities (up to >19:1 dr and >99% ee)- Dataset
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- Enantioselective
- stereocenter
- Vinylogou
- Oxindole
- ee
- stereoselectivitie
- tool
- Nitroolefin Enoates
- vinylogou
- one-pot cascade reaction
- Cascade
- nitroolefin enoates
- bioactive chiral chromans
- dr
- Alkylidene
- yield
- enantioselective construction
- novel bifunctional squaramide
- 3- alkylidene oxindoles