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Proteasome-mediated degradation plays a role in STING reduction.
Abstract
<p>(A) Time course assessment of STING mRNA expression after MRC-5 cells were transfected with pcDNA3.1 (0.05μg). (B) Western blotting assessment of STING after MRC-5 cells were transfected with pcDNA3.1 (0.05μg) with treatment of Bortezomib (20 nM) or DMSO for 18h. (C)Western blotting assessment of immunoprecipitated STING with anti-ubiquitin antibody.</p- Image
- Figure
- Biochemistry
- Microbiology
- Cell Biology
- Genetics
- Molecular Biology
- Immunology
- Developmental Biology
- Cancer
- Infectious Diseases
- Virology
- Biological Sciences not elsewhere classified
- Chemical Sciences not elsewhere classified
- RIG-I siRNA knockdown
- double-stranded DNA
- signal transduction molecule
- DNA sensor pathway
- STING protein
- IL -6 neutralizing antibody
- non-HDC HEK 293 cells
- UNC
- MRC
- STING degradation
- ULK
- IL -6
- IL -6. Employing