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/Author (Bylgja Hilmarsdottir 1, Eirikur Briem 1, Jon Thor Bergthorsson 1,2, Magnus Karl Magnusson 1,2,3 and Thorarinn Gudjonsson 1,2,*)
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/Keywords (miRNAs; miR-200 family; breast; epithelium; branching morphogenesis; EMT; MET; breast cancer)
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/Title (Functional Role of the microRNA-200 Family in Breast Morphogenesis and Neoplasia)
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Functional Role of the microRNA-200 Family in Breast Morphogenesis and Neoplasia
Bylgja Hilmarsdottir 1, Eirikur Briem 1, Jon Thor Bergthorsson 1,2, Magnus Karl Magnusson 1,2,3 and Thorarinn Gudjonsson 1,2,*
Branching epithelial morphogenesis is closely linked to epithelial-to-mesenchymal transition (EMT), a process important in normal development and cancer progression. The miR-200 family regulates epithelial morphogenesis and EMT through a negative feedback loop with the ZEB1 and ZEB2 transcription factors. miR-200 inhibits expression of ZEB1/2 mRNA, which in turn can down-regulate the miR-200 family that further results
in down-regulation of E-cadherin and induction of a mesenchymal phenotype. Recent studies show that the expression of miR-200 genes is high during late pregnancy and lactation, thereby indicating that these miRs are important for breast epithelial morphogenesis and differentiation. miR-200 genes have been studied intensively in relation to breast cancer progression and metastasis, where it has been shown that miR-200 members are down-regulated in basal-like breast cancer where the EMT phenotype is prominent. There is growing evidence that the miR-200 family is up-regulated in distal breast metastasis indicating that these miRs are important for colonization of metastatic breast cancer cells through induction of mesenchymal to epithelial transition. The dual role of miR-200 in primary and metastatic breast cancer is of interest for future therapeutic interventions, making it important to understand its role and interacting partners in more detail.
miRNAs
miR-200 family
breast
epithelium
branching morphogenesis
EMT
MET
breast cancer
Acrobat Distiller 9.0.0 (Windows)
miRNAs; miR-200 family; breast; epithelium; branching morphogenesis; EMT; MET; breast cancer
D:20140910053633
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