%PDF-1.6
%
1 0 obj
<<
/OpenAction 2 0 R
/PageMode /None
/Names 3 0 R
/Metadata 4 0 R
/Lang (en)
/Type /Catalog
/Outlines 5 0 R
/PageLabels <<
/Nums [0 6 0 R]
>>
/Pages 7 0 R
/ViewerPreferences <<
/FitWindow true
>>
>>
endobj
8 0 obj
<<
/Keywords ("lncRNA; glioma; CRNDE; HOTAIR; H19; MEG3; glioblastoma stem cell; biomarker; gliomagenesis")
/Creator (LaTeX with hyperref package)
/ModDate (D:20160607150434+08'00')
/Trapped /False
/CreationDate (D:20150729173451+08'00')
/Producer <7064665465582D312E34302E31333B206D6F646966696564207573696E67206954657874AE20352E352E3620A9323030302D323031352069546578742047726F7570204E5620284147504C2D76657273696F6E29>
/Subject (Long non-coding RNAs \(LncRNAs\) represent a novel class of RNAs with no functional protein-coding ability, yet it has become increasingly clear that interactions between lncRNAs with other molecules are responsible for important gene regulatory functions in various contexts. Given their relatively high expressions in the brain, lncRNAs are now thought to play important roles in normal brain development as well as diverse disease processes including gliomagenesis. Intriguingly, certain lncRNAs are closely associated with the initiation, differentiation, progression, recurrence and stem-like characteristics in glioma, and may therefore be exploited for the purposes of sub-classification, diagnosis and prognosis. LncRNAs may also serve as potential therapeutic targets as well as a novel biomarkers in the treatment of glioma. In this article, the functional aspects of lncRNAs, particularly within the central nervous system \(CNS\), will be briefly discussed, followed by highlights of the important roles of lncRNAs in mediating critical steps during glioma development. In addition, the key lncRNA players and their possible mechanistic pathways associated with gliomagenesis will be addressed.)
/PTEX.Fullbanner (This is pdfTeX, Version 3.1415926-2.4-1.40.13 \(TeX Live 2012/W32TeX\) kpathsea version 6.1.0)
/Author (Karrie Mei-Yee Kiang, Xiao-Qin Zhang and Gilberto Ka-Kit Leung)
/Title (Long Non-Coding RNAs: The Key Players in Glioma Pathogenesis)
>>
endobj
2 0 obj
<<
/S /GoTo
/D [9 0 R /FitH]
>>
endobj
3 0 obj
<<
/Dests 10 0 R
>>
endobj
4 0 obj
<<
/Length 5178
/Subtype /XML
/Type /Metadata
>>
stream
Karrie Mei-Yee Kiang, Xiao-Qin Zhang and Gilberto Ka-Kit Leung
Long non-coding RNAs (LncRNAs) represent a novel class of RNAs with no functional protein-coding ability, yet it has become increasingly clear that interactions between lncRNAs with other molecules are responsible for important gene regulatory functions in various contexts. Given their relatively high expressions in the brain, lncRNAs are now thought to play important roles in normal brain development as well as diverse disease processes including gliomagenesis. Intriguingly, certain lncRNAs are closely associated with the initiation, differentiation, progression, recurrence and stem-like characteristics in glioma, and may therefore be exploited for the purposes of sub-classification, diagnosis and prognosis. LncRNAs may also serve as potential therapeutic targets as well as a novel biomarkers in the treatment of glioma. In this article, the functional aspects of lncRNAs, particularly within the central nervous system (CNS), will be briefly discussed, followed by highlights of the important roles of lncRNAs in mediating critical steps during glioma development. In addition, the key lncRNA players and their possible mechanistic pathways associated with gliomagenesis will be addressed.
Long Non-Coding RNAs: The Key Players in Glioma Pathogenesis
lncRNA; glioma; CRNDE; HOTAIR; H19; MEG3; glioblastoma stem cell; biomarker; gliomagenesis
endstream
endobj
5 0 obj
<<
/Type /Outlines
/Count 15
/First 11 0 R
/Last 12 0 R
>>
endobj
6 0 obj
<<
/St 1406
/S /D
>>
endobj
7 0 obj
<<
/Kids [13 0 R 14 0 R 15 0 R 16 0 R]
/Type /Pages
/Count 20
>>
endobj
9 0 obj
<<
/Contents 17 0 R
/Type /Page
/Resources 18 0 R
/CropBox [0 0 595.276 841.89]
/Parent 13 0 R
/Rotate 0
/MediaBox [0 0 595.276 841.89]
>>
endobj
10 0 obj
<<
/Kids [19 0 R 20 0 R 21 0 R 22 0 R 23 0 R]
/Limits [(Doc-Start) (table.1)]
>>
endobj
11 0 obj
<<
/A 24 0 R
/Next 25 0 R
/Parent 5 0 R
/Title (1. Introduction)
>>
endobj
12 0 obj
<<
/A 26 0 R
/Parent 5 0 R
/Title (8. Conclusions)
/Prev 27 0 R
>>
endobj
13 0 obj
<<
/Kids [28 0 R 9 0 R 29 0 R 30 0 R 31 0 R 32 0 R 33 0 R]
/Type /Pages
/Count 7
/Parent 7 0 R
>>
endobj
14 0 obj
<<
/Kids [34 0 R 35 0 R 36 0 R 37 0 R 38 0 R 39 0 R]
/Type /Pages
/Count 6
/Parent 7 0 R
>>
endobj
15 0 obj
<<
/Kids [40 0 R 41 0 R 42 0 R 43 0 R 44 0 R 45 0 R]
/Type /Pages
/Count 6
/Parent 7 0 R
>>
endobj
16 0 obj
<<
/Kids [46 0 R]
/Type /Pages
/Count 1
/Parent 7 0 R
>>
endobj
17 0 obj
<<
/Length 2043
/Filter /FlateDecode
>>
stream
xڕX[w6~#
a5yY:/Ml9ٴ}(XBM
HFQ`@v$3̇˓oz89)M=Y$K˲y=,_sYx跳~$bOUB8| VA8:aEٔ>( }i(~GE Q
BgE
0$
IW8Y
/K9˒+' 9ˋ+R=|tv| ҡWaڜf 'dONj[:,IC^0cAazw g'80`a'Kі@Y1^ه{vfQE