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The role of cannabinoids in the neurobiology of sensory gating: a firing rate model study

By Margarita Zachariou, Dilshani Dissanayake, Markus R. Owen, Rob Mason and Stephen Coombes

Abstract

Gating of sensory (e.g. auditory) information has been demonstrated as a reduction in the auditory-evoked potential responses recorded in the brain of both normal animals and human subjects. Auditory gating is perturbed in schizophrenic patients and pharmacologically by drugs such as amphetamine, phencyclidine or ketamine, which precipitate schizophrenic-like symptoms in normal subjects. The neurobiological basis underlying this sensory gating can be investigated using local field potential recordings from single electrodes. In this paper we use such technology to investigate the role of cannabinoids in sensory gating. Cannabinoids represent a fundamentally new class of retrograde messengers which are released postsynaptically and bind to presynaptic receptors. In this way they allow fine-tuning of neuronal response, and in particular can lead to so-called depolarization-induced suppression of inhibition (DSI). Our experimental results show that application of the exogenous cannabinoid WIN55, 212-2 can abolish sensory gating as measured by the amplitude of local field responses in rat hippocampal region CA3. Importantly we develop a simple firing rate population model of CA3 and show that gating is heavily dependent upon the presence of a slow inhibitory (GABAB) pathway. Moreover, a simple phenomenological model of cannabinoid dynamics underlying DSI is shown to abolish gating in a manner consistent with our experimental findings

Publisher: Elsevier
Year: 2006
OAI identifier: oai:eprints.nottingham.ac.uk:421
Provided by: Nottingham ePrints

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Citations

  1. (2006). Abolition of sensory gating by the cannabinoid WIN55, 212-2 in the rat hippocampus,
  2. (1990). Auditory sensory gating in hippocampal neurons: A model system in rat,
  3. (1999). Behavioral effects of cannabinoid agents in animals,
  4. (1992). Cholinergic gating of response to auditory stimuli in rat hippocampus,
  5. (2003). Dopaminergic modulation of the P50 auditory-evoked potential in a computer model of the CA3 region of the hippocampus: its relationship to sensory gating in schizophrenia,
  6. (2002). Endocannabinoid signaling in the brain,
  7. (2001). Endogenous cannabinoids mediate retrograde signalling at hippocampal synapses,
  8. (2001). Endogenous cannabinoids mediate retrograde signals from depolarized postsynaptic neurons to presynaptic terminals,
  9. (1972). Excitatory and Inhibitory interactions in localized populations of model neurons,
  10. (2003). Filtering Disturbances in Schizophrenic Patients. Gating of Auditory Evoked Potentials and Prepulse Inhibition of the Acoustic Startle Response Compared. Emphasis on the role of Dopamine,
  11. (1995). GABAB antagonists diminish the inhibitory gating of auditory response in the rat hippocampus,
  12. (2001). Hippocampal and cortical sensory gating in rats: Effects of quinpirole microinjections in nucleus accumbens core and shell,
  13. (2003). Inhibitory control of sensory gating in a computer model of the CA3 region of the hippocampus,
  14. (2002). Inhibitory Deficit in Schizophrenia is Not Necessarily a GABAergic Deficit,
  15. (2004). Modeling Extracellular Field Potentials and the Frequency-Filtering Properties of Extracellular Space,
  16. (1995). Restoration of sensory gating of auditory evoked response by nicotine in fimbria-fornix lesioned rats,
  17. (2003). Role of endogenous cannabinoids in synaptic signalling,
  18. (1996). Sensory gating in a computer model of the CA3 neural network of the hippocampus,
  19. (1995). The activity of hippocampal interneurons and pyramidal cells during the response of the hippocampus to repeated auditory stimuli,
  20. (1997). Towards a Cannabinoid Hypothesis of Schizophrenia: Cognitive Impairments Due to Dysregulation of the Endogenous Cannabinoid System,

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