Skip to main content
Article thumbnail
Location of Repository

Dendritic cable with active spines: a modeling study in the spike-diffuse-spike framework

By Yulia Timofeeva, Gabriel Lord and Stephen Coombes

Abstract

The spike-diffuse-spike (SDS) model describes a passive dendritic tree with active dendritic spines. Spine-head dynamics is modelled with a simple integrate-and-fire process, whilst communication between spines is mediated by the cable equation. Here we develop a computational framework that allows the study of multiple spiking events in a network of such spines embedded in a simple one-dimensional cable. This system is shown to support saltatory waves as a result of the discrete distribution of spines. Moreover, we demonstrate one of the ways to incorporate noise into the spine-head whilst retaining computational tractability of the model. The SDS model sustains a variety of propagating patterns

Year: 2005
OAI identifier: oai:eprints.nottingham.ac.uk:210
Provided by: Nottingham ePrints

Suggested articles

Citations

  1. (1990). Biophysical model of a Hebbian synapse, doi
  2. (1987). Logic operations are properties of computersimulated interactions between excitable dendritic spines, doi
  3. (1991). Propagation of dendritic spikes mediated by excitable spines: A continuum theory,
  4. (2003). Saltatory waves in the spike-diffuse-spike model of active dendritic spines,
  5. (1985). Signal enhancement in distal cortical dendrites by means of interactions between active dendritic spines, doi
  6. (2000). Solitary waves in a model of dendritic cable with active spines,
  7. Spatio-temporal filtering properties of a dendritic cable with active spines: a modelling study in the spike-diffuse-spike framework, doi
  8. (1985). Synaptic amplification by active membrane in dendritic spines,
  9. (2003). The NEURON simulation environment,

To submit an update or takedown request for this paper, please submit an Update/Correction/Removal Request.