The diploma thesis focuses on the research of sibling constellations and other specifics in relation of healthy siblings and physically disadvantaged, particularly for persons with multiple sclerosis, which at the time of the disease for at least some time have not lived in the common household. The research using interviews with respondents is subsequently analyzed from two points of view, both in terms of healthy individuals to disadvantaged and disadvantaged in terms of the healthy. The goal is to specify different views of the both siblings if they are different, which is expected and other peculiarities of their relationship. Then the analysis follows the trends that are present in the relationship of these people. Research will precede acquaintance with issues of multiple sclerosis, especially its potential impact on psychosocial relations and the issue of the relationship between the average healthy adult siblings. The conclusions confirmed details on the specific consistent with the literature, but pronounced tendency in these relationships were not observed, the disease does not significantly affect relationships, which we believe is influenced mainly by the current state of the respondents, who are all stable and mostly take place everyday activities. KEYWORDS multiple sclerosis,..