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Clinical significance and management of sentinel\ud node micrometastasis in invasive breast cancer

By Sadaf Jafferbhoy and Billy McWilliams

Abstract

Axillary node status is one of the most important prognostic indicators in patients with invasive breast cancer. Sentinel\ud node biopsy allows an exhaustive examination of the lymph node and has led to an increased detection rate of small\ud tumor deposits. Patients with micrometastatic deposits can have nonsentinel node involvement, including macrometastatic\ud deposits. Sentinel node micrometastases are associated with an adverse impact on disease recurrence\ud and survival. Axillary dissection does not offer an advantage in reducing the incidence of disease recurrence or\ud survival. However, the long-term outcomes can be improved with the use of adjuvant chemotherapy, and it would be\ud reasonable to consider systemic treatment in these patients

Topics: R1, RC0254
Publisher: Elsevier
Year: 2012
OAI identifier: oai:http://orca.cf.ac.uk:43753
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