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T cell subsets and colorectal cancer: discerning the good from the bad

By Martin John Scurr, Awen Myfanwy Gallimore and Andrew James Godkin

Abstract

Tumor-specific T cells must overcome a multitude of suppressive mechanisms to destroy cancerous cells effectively. Furthermore, it appears that the tumor microenvironment facilitates the development of highly immunosuppressive T cells, which may also allow subsequent tumor progression. In colorectal cancer, the relationship between regulatory T cells (e.g. FoxP3(+) Tregs) and tumor prognosis and progression is less clear, despite their well-documented ability to impinge on anti-tumor immune responses. Here we explore our current knowledge of colorectal TIL heterogeneity, deciphering subsets which may be of benefit or detriment

Topics: RC0254
Publisher: Elsevier
Year: 2012
DOI identifier: 10.1016/j.cellimm.2012.08.004
OAI identifier: oai:http://orca.cf.ac.uk:40136
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