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講座

By 宏一 加藤 and Koichi KATO

Abstract

分子生物学的レベルで子宮筋収縮弛緩機構を検討し,つぎのごとき結論に達した。子宮筋の場合:筋収縮因子Caは静止時筋細胞膜外に存在し,膜がdepolarizationを起した時,Caは筋細胞膜内にpassive Transportで入り,細胞内のActomyosin中のTro-poninに結合して,Myofilamentが収縮する。弛緩の際は,膜のredepolarizationが起こり,筋細胞膜のactive Transportにより,Caは膜外に汲み出され,筋は弛緩する。骨格筋の場合:Caは子宮筋の場合とその態度が異なり,膜内でTroponinとSarcoplasmic reticulumなどの間を往き来して筋の収縮弛緩を行なう。We investigated the contraction and relaxation system of the uterine muscle from the viewpoint of molecular biology and reached the following conclusion. Uterine muscle. Calcium, a muscle contracting factor, remains outside the cell membrane when the muscle isresting; it enters into the muscle cell through the membrane by means of passive transport when the membrane is depolarized and combines with troponin, a component of actomyo sin; this causes the contraction of the myofilament. On the other hand, when the muscle relaxes, redepolarization occurrs in the muscle cell membrane. Calcium is forced out of the membrane by means of active transport of the muscle cell membrane and the muscle relaxes. Skeletal muscle. With the skeletal muscle calcium reacts differently; it moves between troponin and the sarcoplasmic reticulm and thus triggering contraction and relaxation of the skeletal muscle. We conducted a comparative study using both skeletal and uterine muscles. Our data showed a striking difference between the relaxed and contracted muscles in regard to the behaviour of calcium

Topics: Uterine contraction and relaxation
Publisher: 千葉医学会
Year: 1971
OAI identifier: oai:opac.ll.chiba-u.jp:900115207
Journal:

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