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Predictive milling of pharmaceutical materials using nanoindentation of single crystals

By L.J. Taylor, D.G. Papadopoulos, P.J. Dunn, A.C. Bentham, N.J. Dawson, J.C. Mitchell and M.J. Snowden


Five pharmaceutical materials, including two salts and three neutral compounds, have been subjected to nanoindentation analysis on a single-crystal scale. The nanoindentation experiments were used to calculate a brittleness index for each of the five materials. These results were compared to the size reductions that were obtained on a pilot-plant scale mill. A good correlation between single crystal and large pilot-plant scale results was obtained for the range of materials studied

Topics: QD, RS
Publisher: ACS Publications
Year: 2004
DOI identifier: 10.1021/op0300241
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