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Fusome as a Cell-Cell Communication Channel of Drosophila Ovarian Cyst

By Jean-René Huynh

Abstract

In most animal species, female and male gametes are produced within clusters of germ cells which share a common cytoplasm through cell-cell channels. In Drosophila ovaries, these cells synchronise their divisions and specialise one cell of the cluster as the future egg. Both processes are organised by a germline-specific organelle of communication called the fusome. Until recently, the fusome has remained largely mysterious despite a hundred years of research on its composition, formation and functions. Novel results have now suggested several molecular mechanisms to explain how the fusome synchronises the divisions by controlling cell-cycle regulators and how it determines and polarises the future egg by organising the microtubule cytoskeleton. Importantly, a structure similar to the fusome has been identified during Xenopus oogenesis, suggesting that it is widely conserved from invertebrates to vertebrates, and that it thus serves an essential function

Topics: Drosophila, oogenesis, fusome, oocyte, cell-cell channels, cyst, [SDV.BC.IC] Life Sciences [q-bio]/Cellular Biology/Cell Behavior [q-bio.CB]
Publisher: Landes Biosciences
Year: 2005
OAI identifier: oai:HAL:hal-00013440v1
Provided by: Hal-Diderot
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