Skip to main content
Article thumbnail
Location of Repository

Outbreak of West Nile virus causing severe neurological involvement in children, Nuba Mountains, Sudan, 2002.

By E Depoortere, J Kavle, K Keus, H Zeller, S Murri and D Legros

Abstract

An atypical outbreak of West Nile virus (WNV) occurred in Ngorban County, South Kordophan, Sudan, from May to August 2002. We investigated the epidemic and conducted a case-control study in the village of Limon. Blood samples were obtained for cases and controls. Patients with obvious sequelae underwent cerebrospinal fluid (CSF) sampling as well. We used enzyme-linked immunosorbent assay (ELISA) and neutralization tests for laboratory diagnosis and identified 31 cases with encephalitis, four of whom died. Median age was 36 months. Bivariate analysis did not reveal any significant association with the risk factors investigated. Laboratory analysis confirmed presence of IgM antibodies caused by WNV in eight of 13 cases, indicative of recent viral infection. The unique aspects of the WNW outbreak in Sudan, i.e. disease occurrence solely among children and the clinical domination of encephalitis, involving severe neurological sequelae, demonstrate the continuing evolution of WNV virulence. The spread of such a virus to other countries or continents cannot be excluded

Publisher: Wiley-Blackwell
Year: 2004
DOI identifier: 10.1111/j.1365-3156.2004.01253.x
OAI identifier: oai:fieldresearch.msf.org:10144/17724
Provided by: MSF Field Research
Journal:

Suggested articles

Citations

  1. 48; Fax: (+33) 140 21 28 03; E-mail: evelyn.depoortere@msf.be, jkavle@jhsph.edu Kees Keus, Me´decins Sans Frontie`res,
  2. (1956). A study of the ecology of West Nile virus in Egypt.
  3. (1994). Arthropod-borne viral infections associated with a fever outbreak in the northern province of Sudan.
  4. (2002). Bird migration did not bring West Nile virus to New York from Israel.
  5. (2001). Clinical characteristics of the West Nile fever outbreak,
  6. (2001). Comparative symptomatology of West Nile fever.
  7. (2004). E. Depoortere et al. West Nile virus outbreak in Sudan 736 ª
  8. (2004). E. Depoortere et al. West Nile virus outbreak in Sudan ª
  9. (2000). Emerging arboviral encephalitis.
  10. (1996). Evaluation of arthropod-borne viruses and other infectious disease pathogens as the causes of febrile illnesses in the Khartoum Province of Sudan.
  11. (1997). Extensive nucleotide changes and deletions within the envelope glycoprotein gene of Euro-African West Nile viruses.
  12. (2001). Fine A
  13. (2002). First isolation of West Nile virus from a patient with encephalitis in the United States.
  14. (1984). Isolation of West Nile virus from the brains of children who had died of encephalitis.
  15. (2002). Neurological features of West Nile virus infection during the 2000 outbreak in a regional hospital in Israel.
  16. (2000). Nuba Mountains SPLM/A held areas.
  17. (2001). Outbreak of West Nile virus infection,
  18. (1999). Outbreak of West Nile-like viral encephalitis.
  19. (2002). Pathogenesis and clinical features of Japanese encephalitis and West Nile virus infections.
  20. (2002). The ecology and epidemiology of West Nile virus
  21. (2002). The global emergence/resurgence of arboviral diseases as public health problems.
  22. (2002). Vaccine-associated paralytic poliomyelitis in India during 1999: decreased risk despite massive use of oral polio vaccine.
  23. (1998). West Nile encephalitis in south-eastern Romania.
  24. (1999). West Nile fever – a re-emerging mosquito-borne viral disease
  25. (2001). West Nile fever outbreak,
  26. (1989). West Nile fever. In: The Arboviruses Epidemiology
  27. (2001). West Nile outbreak in horses in southern France (2000): the return after 35 years.
  28. (2002). West Nile virus in livestock and wildlife.
  29. (2002). West Nile virus: a primer for the clinician.
  30. (2001). West Nile virus: a re-emerging global pathogen.
  31. (2002). West Nile virus.
  32. (1996). West Nile: a deadly virus?

To submit an update or takedown request for this paper, please submit an Update/Correction/Removal Request.