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Synthesis of the positron-emitting radiotracer [<sup>18</sup>F]-2-fluoro-2-deoxy-d-glucose from resin-bound perfluoroalkylsulfonates

By L.J. Brown, N. Ma, D.R. Bouvet, S. Champion, A.M. Gibson, Y. Hu, A. Jackson, I. Khan, N. Millot, A.C. Topley, H. Wadsworth, D. Wynn and R.C.D. Brown


A new approach to the synthesis of 2-fluoro-2-deoxy-D-glucose (FDG, [19/18F]-3) is described, which employs supported perfluoroalkylsulfonate precursors 33–36, where the support consists of insoluble polystyrene resin beads. Treatment of these resins with [19F]fluoride ion afforded protected FDG [19F]-18 as the major product, and the identities of the main byproducts were determined. Acidic removal of the acetal protecting groups from [19F]-18 was shown to produce [19F]FDG. The method has been applied to the efficient radiosynthesis of the imaging agent [18F]FDG, and was shown to produce the radiochemical tracer in good radiochemical yield (average 73%, decay corrected)

Publisher: 'Royal Society of Chemistry (RSC)'
Year: 2009
DOI identifier: 10.1039/B816032E
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Provided by: Enlighten
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