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Role of the HLA System in the Association Between Multiple Sclerosis and Infectious Mononucleosis

By S.V. Ramagopalan, U. C. Meier, M. Conacher, G. C. Ebers, G. Giovannoni, D. H. Crawford and K.A. McAulay

Abstract

Objective: To determine whether multiple sclerosis (MS) and infectious mononucleosis (IM) share common HLA associations. Design: A prospective cohort study was conducted from October 1, 1999, through September 30, 2003. Setting: University of Edinburgh Richard Verney Health Centre, Edinburgh, Scotland. Patients: Participants included 179 individuals who underwent asymptomatic Epstein-Barr virus seroconversion and 175 patients who developed IM. Intervention: Genotyping for 5 classical HLA loci (HLA-A, HLA-B, HLA-C, HLA-DRB1, and HLA-DQB1). Main Outcome Measure: Diagnosis of IM and allele frequency. Results: Allelic analysis showed that HLA-DRB1*01:01 was significantly associated with the development of IM (odds ratio, 3.2; P < .001). Patients with IM and HLA-DRB1*01:01 had a lower Epstein-Barr virus viral load compared with those without the allele (median, 783 vs 7366 copies/10(6) peripheral blood mononuclear cells; P = .03). Conclusion: HLA-DRB1*01:01 is protective against developing MS; thus, a common genetic basis between IM and MS is not supported

Year: 2011
OAI identifier: oai:eprints.gla.ac.uk:50979
Provided by: Enlighten
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