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The population structure of the Cryptosporidium parvum population in Scotland: a complex picture

By L.J. Morrison, M.E. Mallon, H.V. Smith, A. MacLeod, L. Xiao and A. Tait

Abstract

We genotyped 297 Scottish C parvum samples using micro- and minisatellites. Treated as a single population, the population structure was epidemic. When regional populations were analysed, there was evidence of sub-population structure variations. This was dependent upon excluding sub-groups exhibiting significant genetic distance from the main population, implying genetic sub-structuring. We tested the hypothesis that these sub-groups originated outside the UK and demonstrated that one sub-group clustered with Peruvian samples. A geographically comprehensive panel of isolates would fully confirm this result. These data indicate limited sub-structuring within a small geographical area, but substantial sub-structuring over larger geographical distances. Host movement influences parasite diversity and population structure, evidenced by strong correlation (r(2) = 0.9686) between cattle movements and parasite diversity. Thus, the population structure of C parvum is complex, with sub-populations differing in structure and being influenced by host movements, including the introduction of novel multilocus genotypes from geographically distinct regions

Publisher: 'Elsevier BV'
Year: 2008
DOI identifier: 10.1016/j.meegid.2007.10.010
OAI identifier: oai:eprints.gla.ac.uk:45696
Provided by: Enlighten
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