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Pedagogical view of model metabolic cycles

By Victor García-Herrero and Antonio Sillero


The main purpose of this study was to present a simplified view of model metabolic cycles. Although the models have been elaborated with the Mathematica Program, and using a system of differential equations, the main conclusions were presented in a rather intuitive way, easily understandable by students of general courses of Biochemistry, and without any need of mathematical support. A change in any kinetic constant (Km or Vmax) of only one enzyme affected the metabolic profile of all the substrates of the cycle. In addition, it is shown how an increase in the Km or a decrease in the Vmax values of any particular enzyme promoted an increase of its substrate; the contrary occurred decreasing the Km or increasing the Vmax values.This investigation was supported by Grant BFU2009-08977.Peer Reviewe

Topics: Differential equations, Enzyme kinetics, Mathematica program, Irreversible pathway, Metabolic cycle
Publisher: 'Wiley'
Year: 2017
DOI identifier: 10.1002/bmb.20920
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Provided by: Digital.CSIC
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