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ANTIBODIES TO HUMAN PAPILLOMAVIRUS TYPE-16 E7 RELATED TO CLINICOPATHOLOGICAL DATA IN PATIENTS WITH CERVICAL-CARCINOMA

By MFD BAAY, JM DUK, MPM BURGER, J WALBOOMERS, J TERSCHEGGET, KH GROENIER, HWA DEBRUIJN, E STOLZ and P HERBRINK

Abstract

Aims-To investigate the correlation between antibodies to the transforming protein E7 of human papillomavirus (HPV) type 16 and clinicopathological indices in women with cervical squamous carcinoma. Methods-A synthetic peptide of the HPV type 16 E7 protein (amino acids 6 to 35) was used to screen sera from 29 children, 130 women with cervical intraepithelial neoplasia, 443 women with cervical cancer, and 222 controls, for antibodies against this viral antigen. Bivariate and multivariate analyses were used to investigate the correlation between the serological status in the pretreatment sera and clinicopathological indices (size of the lesion, histological grade, stromal infiltration, vascular invasion, and nodal spread). Survival analysis was done using the Cox regression model for all FIGO stages and stages IB and IIA. Results-Cervical carcinoma patients had a significantly higher prevalence of antibodies to synthetic peptide E7\6-35 than women with cervical intraepithelial neoplasia (17.7% v 7%, p Conclusions-The presence of antibodies against E7\6-35 in pretreatment sera from patients with cervical carcinoma correlates with the size of the lesion, lymph node involvement, and a worse prognosis

Topics: HUMAN PAPILLOMAVIRUS, CERVICAL CANCER, ANTIBODY RESPONSE, UTERINE CERVIX, CANCER, CELL, IDENTIFICATION, PROTEINS, EPITOPES, EXPRESSION, MARKERS, SERA, E6
Year: 1995
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Provided by: NARCIS
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