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Comparison of Intra-voxel Incoherent Motion Diffusion Magnetic Resonance Imaging and Apparent Diffusion Coefficient in the Evaluation of Focal Malignant Liver Masses

By Jinrong Qu, Xiang Li, Lei Qin, Lifeng Wang, Junpeng Luo, Jianwei Zhang, Hongkai Zhang, Jing Li, Fei Sun, Shouning Zhang, Yanle Li, Cuicui Liu and Hailiang Li


Aim: To compare the apparent diffusion coefficient (ADC) derived from conventional diffusion-weighted imaging (DWI), and parameters derived from intra-voxel incoherent motion (IVIM) diffusion, in the differentiation of common focal malignant liver masses. Methods: DWI of 53 patients with 85 focal liver masses (47 hepatocellular cancers [HCCs], 18 cholangiocarcinomas, and 20 metastases) were recruited to receive a 3.0T MR scanner with 2 b values (0, 700 s/mm [2]) to measure the ADC values and with 7 b values (0, 50, 100, 250, 500, 750, 1000 s/mm [2] ) to measure IVIM derived parameters: true diffusion coefficient (D), perfusion related diffusion coefficient (DFNx01) and perfusion fraction (f). The mean of each parameter was compared by the Dunnett multiple comparison test. Results: Both ADC and D were significantly higher in cholangiocarcinomas than in HCCs (ADC: 1.49 ± 0.27 × 10−3 vs. 1.20 ± 0.26 × 10−3 mm 2 /s and D: 0.94 ± 0.17 × 10−3 vs. 0.53 ± 0.23 × 10−3 mm 2 /s, respectively; P = 0.002 and P < 0.001) with D providing higher areas under the receiver operating characteristic curve of 0.936 and ADC 0.794. Neither ADC nor IVIM derived parameters could differentiate metastases from HCCs and cholangiocarcinomas. Conclusion: D improved the accuracy of differentiating HCCs and cholangiocarcinomas compared to ADC

Topics: Diffusion-weighted imaging, hepatocellular cancer, intra-voxel incoherent motion, liver neoplasm, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282
Publisher: Wolters Kluwer Medknow Publications
Year: 2015
DOI identifier: 10.4103/2395-3977.151473
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