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The mRNA cap-binding protein eIF4E in post-transcriptional gene expression

By Tobias von der Haar, John D. Gross, Gerhard Wagner and John E. G. McCarthy

Abstract

Eukaryotic initiation factor 4E (eIF4E) has central roles in the control of several aspects of post-transcriptional gene expression and thereby affects developmental processes. It is also implicated in human diseases. This review explores the relationship between structural, biochemical and biophysical aspects of eIF4E and its function in vivo, including both long-established roles in translation and newly emerging ones in nuclear export and mRNA decay pathways

Topics: Q
Publisher: NATURE PUBLISHING GROUP, 345 PARK AVE SOUTH, NEW YORK, NY 10010-1707 USA
Year: 2004
OAI identifier: oai:kar.kent.ac.uk:5337

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