Skip to main content
Article thumbnail
Location of Repository

Nuclear expression of the c-erbB-4/HER-4 growth factor receptor in invasive breast cancers

By Radhika Srinivasan, Cheryl Gillett, Diana M Barnes and William J. Gullick

Abstract

The prevalence and sites of expression of the c-erbB-4 receptor have been determined by immunocytochemical staining in a series of 178 human breast cancers. Most tumors displayed cytoplasmic staining of variable intensity. When compared with adjacent normal tissue, 32 cases (18%) showed lower than normal expression, and 13 (7%) showed greater than normal expression. Nuclear immunoreactivity, confirmed by two different antibodies, was present in 87 cancers (49%) but was found in normal adjacent breast epithelial cells in <5% of cases. There were no significant associations with cytoplasmic or membrane immunoreactivity, but cases showing nuclear expression in >25% of cells were associated with good histological grade, epidermal growth factor receptor expression, c-erbB-3 positivity, cripto, amphiregulin, and transforming growth factor-alpha overexpression

Topics: Q, RC0254
Publisher: American Association for Cancer Research
Year: 2000
OAI identifier: oai:kar.kent.ac.uk:3996
Download PDF:
Sorry, we are unable to provide the full text but you may find it at the following location(s):
  • http://kar.kent.ac.uk/3996/1/t... (external link)
  • http://cancerres.aacrjournals.... (external link)
  • Suggested articles


    To submit an update or takedown request for this paper, please submit an Update/Correction/Removal Request.