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Neuregulin 1-alpha expression in locally advanced breast cancer

By E.H. Raj, A. Skinner, U. Mahji, K.N. Nirmala, K. Ravichandran, V. Shanta, Helen C. Hurst, William J. Gullick and T. Rajkumar


The human Neuregulin 1 (NRG1) gene encodes several alternatively spliced ligands that bind to both c-erbB-3 and c-erbB-4, members of the family of type 1 tyrosine kinase growth factor receptors. Antibodies raised to a synthetic peptide recognize selectively the alpha variant of NRG1. The NRG1-alpha isoforms' expression was studied in 115 locally advanced adenocarcinomas of the breast using immunohistochemistry. Absent or low levels of NRG1-alpha were found to be associated with poorer prognosis compared to tumours that had moderate to high levels of the protein

Topics: Q, RC0254
Publisher: Elsevier Science B.V., Amsterdam
Year: 2001
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