Skip to main content
Article thumbnail
Location of Repository

Heparin-binding epidermal growth factor and its receptors mediate decidualization and potentiate survival of human endometrial stromal cells

By Katya Chobotova, Natalia Karpovich, Janet Carver, Sanjiv Manek, William J. Gullick, David Barlow and Helen J. Mardon

Abstract

Heparin-binding epidermal growth factor (HB-EGF) has pleiotropic biological functions in many tissues, including those of the female reproductive tract. It facilitates embryo development and mediates implantation and is thought to have a function in endometrial receptivity and maturation. The mature HB-EGF molecule manifests its activity as either a soluble factor (sol-HB-EGF) or a transmembrane precursor (tm-HB-EGF) and can bind two receptors, EGFR and ErbB4/HER4. In this study, we identify factors that modulate expression of HB-EGF, EGFR, and ErbB4 in endometrial stromal cells in vitro. We demonstrate that levels of sol- and tm-HB-EGF, EGFR, and ErbB4 are increased by cAMP, a potent inducer of decidualization of the endometrial stroma. We also show that production of sol- and tm-HB-EGF is differentially modulated by TNF alpha and TGF beta. Our data suggest that HB-EGF has a function in endometrial maturation in mediating decidualization and attenuating TNF alpha- and TGF beta-induced apoptosis of endometrial stromal cells

Topics: Q, RC0254
Publisher: Endocrine Society
Year: 2005
OAI identifier: oai:kar.kent.ac.uk:3975
Download PDF:
Sorry, we are unable to provide the full text but you may find it at the following location(s):
  • http://kar.kent.ac.uk/3975/1/G... (external link)
  • http://dx.doi.org/10.1210/jc.2... (external link)
  • Suggested articles


    To submit an update or takedown request for this paper, please submit an Update/Correction/Removal Request.