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X-ray diffraction and solid state NMR studies of the growth of hydroxyapatite on bioactive calcia : silica sol-gel glasses

By Laura J. Skipper, Frank E. Sowrey, Rumana Rashid, Robert J. Newport, Z. Lin and Mark E. Smith


An advanced materials characterisation methodology has been used to examine systematically a range of sol-gel glass materials of contemporary biomedical interest. High energy X-ray total diffraction, X-ray fluorescence and Raman spectroscopy, and isotope-enriched O-17 and P-31 MAS NMR have been used to study the local calcium environment in four sol-gel derived bioactive calcium silicate glasses of the general formula (CaO)(x)(SiO2)(1-x), and to gain an atomic scale insight into the nature of the processes initiated when this bioactive glass is immersed in vitro in simulated body fluid (SBF). The results reveal a rapid dissolution of the labile surface calcium ions from the glass within 30 min of immersion in SBF and the later formation of a hydroxyapatite like layer, which MAS NMR suggests is partially ordered locally, but which X-ray diffraction confirms as amorphous overall Annealing the samples at 650 degrees C allows this layer to crystallise, revealing the anticipated hydroxyapatite layer more clearly. The results presented here are consistent with, but greatly extend our previous XRD, Ca-43 and Si-29 MAS-NMR, XANES and EXAFS studies of these materials

Topics: Q
Publisher: Soc Glass Technology
Year: 2005
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