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Aldol reaction of butane-2,3-diacetal protected methyl glycerate

By S. E. Fern, Peter Heath and Alexander John Andre Cobb


The addition of aldehydes to butane-2,3-diacetal has been investigated. The reaction was shown to be both regioselective and diastereoselective by 1H NMR spectroscopy. The configuration of the newly formed stereocenter was determined by Mosher’s ester analysis

Publisher: Elsevier
Year: 2011
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