Location of Repository

Self-immolative linkers in polymeric delivery systems

By Christopher A Blencowe, Andrew T Russell, Francesca Greco, Wayne Hayes and David W Thornthwaite

Abstract

There has been significant interest in the methodologies of controlled release for a diverse range of applications spanning drug delivery, biological and chemical sensors, and diagnostics. The advancement in novel substrate-polymer coupling moieties has led to the discovery of self-immolative linkers. This new class of linker has gained popularity in recent years in polymeric release technology as a result of stable bond formation between protecting and leaving groups, which becomes labile upon activation, leading to the rapid disassembly of the parent polymer. This ability has prompted numerous studies into the design and development of self-immolative linkers and the kinetics surrounding their disassembly. This review details the main concepts that underpin self-immolative linker technologies that feature in polymeric or dendritic conjugate systems and outlines the chemistries of amplified self-immolative elimination

Publisher: Royal Society of Chemistry
Year: 2011
OAI identifier: oai:centaur.reading.ac.uk:16420

Suggested articles

Preview

Citations

  1. (2010). 95 Sci. Part A: Polym. Chem.,
  2. (2008). Anti-Cancer Agent Med. Chem.,
  3. (2002). Anticancer Agents,
  4. (2001). Barbas III,
  5. (1999). Bioconjugate Chem.,
  6. (2006). Controlled Release,
  7. (2008). Drug Dis.,
  8. (2006). Nature Rev. Cancer,
  9. Whiteknights, Reading, RG6 6AD, United Kingdom.

To submit an update or takedown request for this paper, please submit an Update/Correction/Removal Request.