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Evaluating Changes in Omega-3 Fatty Acid Intake after Receiving Personal FADS1 Genetic Information: A Randomized Nutrigenetic Intervention

By Kaitlin Roke, Kathryn Walton, Shannon L. Klingel, Amber Harnett, Sanjeena Subedi, Jess Haines and David M. Mutch

Abstract

Nutrigenetics research is anticipated to lay the foundation for personalized dietary recommendations; however, it remains unclear if providing individuals with their personal genetic information changes dietary behaviors. Our objective was to evaluate if providing information for a common variant in the fatty acid desaturase 1 (FADS1) gene changed omega-3 fatty acid (FA) intake and blood levels in young female adults (18–25 years). Participants were randomized into Genetic (intervention) and Non-Genetic (control) groups, with measurements taken at Baseline and Final (12 weeks). Dietary intake of eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) was assessed using an omega-3 food frequency questionnaire. Red blood cell (RBC) FA content was quantified by gas chromatography. Implications of participation in a nutrigenetics study and awareness of omega-3 FAs were assessed with online questionnaires. Upon completion of the study, EPA and DHA intake increased significantly (p = 1.0 × 10−4) in all participants. This change was reflected by small increases in RBC %EPA. Participants in the Genetic group showed increased awareness of omega-3 terminology by the end of the study, reported that the dietary recommendations were more useful, and rated cost as a barrier to omega-3 consumption less often than those in the Non-Genetic group. Providing participants FADS1 genetic information did not appear to influence omega-3 intake during the 12 weeks, but did change perceptions and behaviors related to omega-3 FAs in this timeframe

Topics: omega-3 fats, nutrigenomics, personalized nutrition, eicosapentaenoic acid, EPA, docosahexaenoic acid, DHA, single nucleotide polymorphisms, SNPs, fatty acid desaturase 1, Nutrition. Foods and food supply, TX341-641
Publisher: MDPI AG
Year: 2017
DOI identifier: 10.3390/nu9030240
OAI identifier: oai:doaj.org/article:fb6239fd61414490b7582024ebd0ff07
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