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Probing the effect of allylic substitution on cyclic ammonium ylid rearrangements

By J. Sançon and J. B. Sweeney

Abstract

The [2,3]-sigmatropic rearrangement of tetrahydropyridine-derived ammonium ylids is a valuable method for the preparation of substituted pyrrolidine carboxylates. The presence of an allylic substituent does not intrinsically reduce the yield of rearrangements, and the diastereoselectivity of rearrangement is related to the structure of the diazo reactant. The method represents a very rapid means of accessing complex pyrrolidines, as shown by preparation of a precursor to the core of lactacystin

Publisher: Thieme
Year: 2010
OAI identifier: oai:centaur.reading.ac.uk:16739
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