Skip to main content
Article thumbnail
Location of Repository

A mapping and evolutionary study of porcine sex chromosome genes.

By Claire R Quilter, Sarah C Blott, Alan J Mileham, Nabeel Affara, Carole A Sargent and Darren K. Griffin

Abstract

A combination of FISH and RH mapping was used to study the evolution of sex chromosome genes in the pig. In total, 19 genes were identified, including 3 PAR genes (STS, KAL, PRK). The gene order of the porcine X Chromosome (Chr) closely resembled the human X Chr (PRK/STS/KAL-AMELX-EIF2s3X/ZFX-USP9X-DBX-SMCX), suggesting that the porcine X has undergone very little rearrangement during evolution. For the porcine Y Chr, two linkage groups of 10 NRY genes were found, and the following order was established: Ypter-(AMELY-EIF2S3Y/ZFY-USP9Y-DBY/UTY)-(TSPY-SMCY-UBE1Y-SRY)-CEN. This gene order showed greater conservation with the murine Y than with the human Y Chr. In addition, all porcine Y Chr genes mapped to Yp, which is similar to the mouse and included EIF2s3Y and UBE1Y, which are not present in humans. Interestingly, complete conservation of X/Y homologous gene order was found between the pig X and Y Chrs, indicating that the porcine Y Chr has not undergone extensive reorganisation with respect to the X. This suggests that the order of the X/Y homologous genes of the porcine X and Y Chrs may closely resemble the ancestral gene order of the eutherian sex chromosomes

Topics: Q
Publisher: Springer-Verlag
Year: 2002
OAI identifier: oai:kar.kent.ac.uk:102
Download PDF:
Sorry, we are unable to provide the full text but you may find it at the following location(s):
  • http://kar.kent.ac.uk/102/1/Qu... (external link)
  • http://dx.doi.org/10.1007/s003... (external link)
  • http://www.ncbi.nlm.nih.gov/en... (external link)
  • Suggested articles


    To submit an update or takedown request for this paper, please submit an Update/Correction/Removal Request.