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Purification and functional characterisation of rhiminopeptidase A, a novel aminopeptidase from the venom of Bitis gabonica rhinoceros

By Sakthivel Vaiyapuri, Simon C Wagstaff, Kimberly Ann Watson, R. A. Harrison, Jonathan Martin Gibbins and E. Gail Hutchinson

Abstract

This study describes the discovery and characterisation of a novel aminopeptidase A from the venom of B. g. rhinoceros and highlights its potential biological importance. Similar to mammalian aminopeptidases, rhiminopeptidase A might be capable of playing roles in altering the blood pressure and brain function of victims. Furthermore, it could have additional effects on the biological functions of other host proteins by cleaving their N-terminal amino acids. This study points towards the importance of complete analysis of individual components of snake venom in order to develop effective therapies for snake bites

Publisher: Public Library of Science
Year: 2010
OAI identifier: oai:centaur.reading.ac.uk:17906

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