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Sarcoidosis and Thyroid Autoimmunity

By Piera Fazzi, Poupak Fallahi and Silvia Martina Ferrari

Abstract

Most of the studies have shown a higher risk for subclinical and clinical hypothyroidism, antithyroid autoantibodies [overall antithyroid peroxidase antibodies (TPOAb)], and in general, thyroid autoimmunity, overall in the female gender in patients with sarcoidosis (S). A significantly higher prevalence of clinical hypothyroidism and Graves’ disease was also described in female S patients with respect to controls. Gallium-67 (Ga-67) scyntigraphy in S patients, in the case of thyroid uptake, suggests the presence of aggressive autoimmune thyroiditis and hypothyroidism. For this reason, ultrasonography and thyroid function should be done in the case of Ga-67 thyroid uptake. In conclusion, thyroid function, TPOAb measurement, and ultrasonography should be done to assess the clinical profile in female S patients, and the ones at high risk (female individuals, with TPOAb positivity, and hypoechoic and small thyroid) should have periodically thyroid function evaluations and suitable treatments

Topics: sarcoidosis, autoimmune thyroiditis, hypothyroidism, Graves’ disease, antithyroid peroxidase antibodies, thyroglobulin antibodies, Diseases of the endocrine glands. Clinical endocrinology, RC648-665
Publisher: Frontiers Media S.A.
Year: 2017
DOI identifier: 10.3389/fendo.2017.00177/full
OAI identifier: oai:doaj.org/article:12d0eef5923c41b796f1d225c4ee178b
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