Location of Repository

Antipyretic activity of azima tetracantha in experimental animals

By Int J Cur Biomed Phar Res. Arumugam Vijaya Anand Mohamed Hussain Muhammad Ilyas Tajuddin Nargis Begum

Abstract

In the present study, the ethanolic leaf extract of Azima tetracantha Lam (A. tetracantha) was investigated for antipyretic activity in rats using Brewer’s yeast induced Pyrexia. The leaves of A. tetracantha were collected from Ponnamaravathi and cut into small pieces and shade dried. The dried powdered leaves (100 gm) were extracted in a Soxhlet apparatus by using 95% ethanol. Albino rats weighing (200-250g) were taken for the experiment divided into four groups of six animals each. Group 1 received 3% aqueous suspension of gum Acacia (1 ml/200g) as vehicle orally, group 2 and group 3 received ethanolic leaf extract of A. tetracantha 100 and 200 mg/kg with 3% aqueous suspension of gum Acacia orally and the group 4 served as standard received paracetamol 25 mg/kg with 3% aqueous suspension of gum Acacia orally. The subcutaneous injection of yeast suspension markedly elevated the rectal temperature after 18h of administration. Treatment with A. tetracantha extract at a dose of 100, 200 mg/kg decreased the rectal temperature of the rats in dose dependent manner. This effect was maximal at dose of 200 mg/kg and it caused significant lowering of body temperature (P< 0.01) up to 4 hour after its administration. The antipyretic effect started as early as 1h and the effect was maintained for 4h, after its administration. Both the standard drug paracetamol 25 mg/kg and tested drug A. tetracantha extract were significantly reduced the yeast elevated rectal temperature, at 2nd, 3rd and 4th hour compared to control group

Topics: JOURNALS
Publisher: CurrentSciDirect Publications
Year: 2011
OAI identifier: oai:cogprints.org:7331
Download PDF:
Sorry, we are unable to provide the full text but you may find it at the following location(s):
  • http://cogprints.org/7331/1/An... (external link)
  • http://cogprints.org/7331/ (external link)
  • Suggested articles

    Preview

    Citations

    1. (2005). Analgesic and antipyretic activities of aqueous extract of Urtica macrorrhiza in experimental animals. Fitoterapia.
    2. (2005). analgesic and muscle relaxant activities of pueraria isoflavonoids and their metabolites from Pueraria lobata Ohwi- a traditional Chinese drug. Biological and Pharmaceutical Bulletin.
    3. (1997). Anti-inflammatory and antipyretic activity of Michelia champaca Linn. (White variety). Ixora brachiata Roxb and Rhynchosia cana (wild.) D.C. flower extract. Indian J Exp Biol.
    4. (2006). anti-inflammatory and antipyretic effects of Solanum nigrum choloroform extract in animal models. The Pharmaceutical society of Japan.
    5. (1989). Anti-inflammatory properties of flavonoids. Journal de pharmacie de Belgique.
    6. (2003). Antipyretic and analgesic effect of Solanum melongena.
    7. (2001). Bioflavonoids classification,pharmacological, biochemical effects and therapeutic potential.
    8. (1971). Food browning as a polyphenol reaction. In:
    9. (2006). hypoglycaemic and hepatoprotective activities of ethyl acetate extract of Acacia catechu willd in albino rats.
    10. (2004). Puerarin acts through brain serotoninergic mechanism to induce thermal effects. Journal of Pharmacological Sciences.

    To submit an update or takedown request for this paper, please submit an Update/Correction/Removal Request.