Article thumbnail

Ultrastructural Changes in Rat’s Atrial Cardiomyocytes After Short Term Administration of Amiodarone and Possible Protective Role of Vitamin E

By Abdullah S. Shatoor, Mohamed Samir Ahmad Zaki, Refaat A. Eid and Mohamed A. Sayed-Ahmad
Topics: Original Article
Publisher: Elmer Press
OAI identifier:
Provided by: PubMed Central

Suggested articles


  1. A classification of antiarrhythmic actions reassessed after a decade of new drugs.
  2. (2006). Acute onset of halos and glare bilateralcorneal epithelial edema with cystic eruptionsatypical presentation of amiodarone keratopathy.
  3. Amiodarone causes acute oxidant lung injury in ventilated and perfused
  4. Amiodarone in patients with congestive heart failure and asymptomatic ventricular arrhythmia. Survival Trial of Antiarrhythmic Therapy in Congestive Heart Failure.
  5. Amiodarone induced skin necrosis.
  6. (1990). Amiodarone inhibits the mitochondrial beta-oxidation of fatty acids and produces microvesicular steatosis of the liver in mice. J Pharmacol Exp Ther.
  7. (1988). Amiodarone-induced liver toxicity. Ann Intern Med.
  8. Amiodarone-induced pulmonary toxicity: an under-recognized and severe adverse effect? Clin Res Cardiol.
  9. Amiodarone: historical development and pharmacologic profile.
  10. Amiodarone: review of pulmonary effects and toxicity. Drug Saf.
  11. and long-term effects of amiodarone on the two components of cardiac delayed rectifier K(+) current.
  12. Antioxidant vitamins attenuate oxidative stress and cardiac dysfunction in tachycardia-induced cardiomyopathy.
  13. (2001). Antioxidant vitamins prevent cardiomyocyte apoptosis produced by norepinephrine infusion in ferrets. Cardiovasc Res.
  14. Attenuation of amiodarone-induced pulmonary fibrosis by vitamin E is associated with suppression of transforming growth factor-beta1 gene expression but not prevention of mitochondrial dysfunction.
  15. (1975). Cellular reaction to injury. In:
  16. (1996). Distribution of immunoreactive atrial and brain natriuretic peptides in the heart of the chicken, quail, snake and frog. Exp Anim.
  17. (1990). Dual effect of amiodarone on mitochondrial respiration. Initial protonophoric uncoupling effect followed by inhibition of the respiratory chain at the levels of complex I and complex II. J Pharmacol Exp Ther.
  18. (1996). Effect of amiodarone on clinical status and left ventricular function in patients with congestive heart failure.
  19. (2011). Effect of long-term administration of amiodarone on rat lung and the possible protective role of vitamin E: a histological and immunohistochemical study.
  20. (1976). Effects of amiodarone and L8040, novel antianginal and antiarrhythmic drugs, on cardiac and coronary haemodynamics and on cardiac intracellular potentials. Clin Exp Pharmacol Physiol.
  21. Effects of amiodarone on thyroid function.
  22. Effects of dietary vitamin E supplementation on pulmonary morphology and collagen deposition in amiodarone- and vehicle-treated hamsters.
  23. (1964). Evaluation of drug activities and pharmacometrics.
  24. Evidence-based analysis of amiodarone efficacy and safety.
  25. Fine structure of atrial natriuretic peptide (ANP)-granules in the atrial cardiocytes in the hamster, guinea pig, rabbit, cat and dog.
  26. (1991). Fine structure of atrial natriuretic peptide(ANP)-granules in the atrial cardiocytes in the pig, cattle and horse.
  27. (1996). Guide for the Care and Use of Laboratory Animals.
  28. Hemodynamic and electrocardiographic effects of graded doses of amiodarone in healthy dogs anesthetized with morphine/alpha chloralose.
  29. (1990). Histopathologic analysis of suspected amiodarone hepatotoxicity. Hum Pathol.
  30. (2011). Identification of the window period for oxidative stress intervention.
  31. Impairment of the myocardial ultrastructure and changes of the cytoskeleton in dilated cardiomyopathy.
  32. Investigation of the role of oxidative stress in amiodarone-induced pulmonary toxicity in the hamster.
  33. (2004). Progressive apoptotic cell death triggered by transient oxidative insult result H9c2 rat ventricular cells: a novel pattern of apoptosis and the mechanism.
  34. (1994). Randomised trial of low-dose amiodarone in severe congestive heart failure.
  35. Role of mitochondria in oxidative stress and ageing.
  36. Role of vitamin-E on rat liver-amiodarone: an ultrastructural study.
  37. (1976). Sarcolemmal alterations in cardiac hypertrophy and degeneration. Recent Adv Stud Cardiac Struct Metab.
  38. The role of free radicals in the pathogenesis of amiodarone toxicity.
  39. (1996). Theory and practice of histological techniques,
  40. Toxic and therapeutic effects of amiodarone in the treatment of cardiac arrhythmias.
  41. Toxicity of amiodarone and amiodarone analogues on isolated rat liver mitochondria.
  42. (1996). Toxicity of amiodarone on mouse pulmonary endothelial cells cultured with or without alveolar macrophages.
  43. (1973). Ultrastructural pathologic characteristics of the skeletal muscle fiber: An introductory survey. In:
  44. (1975). Ultrastructural Pathology of the Cell. A Text and
  45. Vitamin E inhibits hepatic NF-kappaB activation in rats administered the hepatic tumor promoter, phenobarbital.
  46. (2009). Window Period for Oxidative Stress Attenuating Intervention

To submit an update or takedown request for this paper, please submit an Update/Correction/Removal Request.