Article thumbnail

Therapeutic apheresis in peripheral and retinal circulatory disorders

By Alfonso Ramunni, Paola Brescia, Giuseppina De Fino, Giovanni Piscopo and Loreto Gesualdo


In microcirculation disorders, the therapeutic apheresis seems to have two different effects. The first, achieved after only a few sessions, is acute, consisting of drastic reduction of blood viscosity and obtained with the use of low-density lipoprotein (LDL) apheresis, rheopheresis, or fibrinogen apheresis. The second effect is long term, or chronic, and needs to be evaluated after a long course of treatment. The mechanisms underlying the chronic effect are still objects of debate and take into account the pleiotropic effects of apheresis. However, it is likely that the acute effect of apheresis mainly influences the functional components of the vascular damage, and so the derived rheological benefit might last only for a short period. The chronic effect, on the contrary, by acting on the morphological alterations of the vascular walls, requires the apheresis treatment to be prolonged for a longer period or even cycles of treatment to be programmed

Topics: Article
Publisher: Springer-Verlag
OAI identifier:
Provided by: PubMed Central

Suggested articles


  1. Matsuzaki H, H, coronary plaque regression by low density
  2. Ramunni A, extracorporeal calcifications.
  3. Ramunni Tullio of progenitor cells in
  4. Saliani of study.

To submit an update or takedown request for this paper, please submit an Update/Correction/Removal Request.