Location of Repository

Effects of Acute Recombinant Human TSH on Serum Ghrelin Levels

By Cristina Ciuoli, Lucia Brusco, Alexandra Theodoropoulou, Maria Grazia Castagna, Ornella Neri, Letizia Pasqui and Furio Pacini

Abstract

Recent findings showed the presence of a reciprocal relationship between thyroid hormones and ghrelin, although the exact mechanism is not known. Design: Our study is addressed to evaluate the effect of acute exogenous rhTSH administration on serum ghrelin levels in athyreotic patients on replacement l-thyroxine therapy. The study group included 50 patients (16 males and 34 females) submitted to total thyroidectomy and 131-iodine remnant ablation for differentiated thyroid cancer on l-thyroxine therapy. Mean age was 47.5 ± 16.5 years and mean BMI was 25.6 ± 5.01 kg/m2. rhTSH was administrated at the dosage of 0.9 mg i.m. once daily for two consecutive days. Blood samples were taken between 08.00 and 09.00 after a overnight fasting for measurement of TSH, FT3, FT4, and ghrelin before the first administration of rhTSH and for measurement of TSH and ghrelin 24, 48, 72, and 96 h after the first administration of rhTSH. Results: Mean ± SD values of basal TSH were 0.54 ± 0.77 μU/ml without significant difference between females and males. As expected, after rhTSH administration TSH concentrations increased at 24 and 48 h with peak TSH values ranging from 20.20 to 313 μU/ml (mean ± SD 98.4 ± 66.7 μU/ml). Mean ± SD values of basal ghrelin were 1085 ± 373 pg/ml without significant difference between males and females. After rhTSH administration ghrelin concentrations decreased significantly (p < 0.01) at 24 h (mean ± SD 934 ± 314 pg/ml p < 0.01) and returned to pre-treatment levels at 96 h. Conclusion: Our study demonstrates that acute exogenous TSH administration has a suppressive effect on ghrelin secretion independent from changes in thyroid status

Topics: Endocrinology
Publisher: Frontiers Research Foundation
OAI identifier: oai:pubmedcentral.nih.gov:3356021
Provided by: PubMed Central
Download PDF:
Sorry, we are unable to provide the full text but you may find it at the following location(s):
  • http://www.pubmedcentral.nih.g... (external link)
  • Suggested articles

    Preview

    Citations

    1. (2005). Circulating ghrelin in thyroid dysfunction is related to insulin-resistance and hunger, food-intake or anthropometric changes.
    2. (2009). Expression of ghrelin and its receptor in human tissues.
    3. (2009). Expression of obestatin and ghrelin in papillary thyroid carcinoma.
    4. (2010). Ghrelin affects the hypothalamus-pituitarythyroidaxisinhumansbyincreasing free thyroxine and decreasing TSH in plasma.
    5. (2010). Ghrelin and PYY (3–36) in gastrectomized and vagotomized patients: relations with appetite, energy intake, and resting energy expenditure.
    6. (2007). Ghrelin in neuroendocrine organs and tumors.
    7. (2005). Ghrelin: structure and function.
    8. (2003). Hyperthyroidism is associated with suppressed circulating ghrelin levels.
    9. (2004). Plasma ghrelin concentrations,food intake, and anorexia in liver failure.
    10. (2009). Plasma total and acylated ghrelin concentrations in patients with clinical and subclinical thryoid dysfunction.
    11. (2006). Radioiodine ablation of thyroid remnants after preparation with recombinant human thyrotropin in differentiated thyroid carcinoma: results of an international, randomized, controlled study.
    12. (2006). Reduced serum acylated ghrelin levels in patients with hyperthyroidism.
    13. (2005). Secretory dynamics of ghrelin in adolescent girls with anorexia nervosa and healthy adolescents.
    14. (2006). Serumghrelinlevelsinpatientswith Hashimoto’s thyroiditis.
    15. (2000). The novel hypothalamic peptide ghrelin stimulates food intake and growth hormone secretion.
    16. (2011). TheodoropoulouA,Castagna MG,Neri O,Pasqui L and Pacini F
    17. (2002). Thetissuedistributionof themRNA of ghrelin and subtypes of its receptor, GHS-R, in humans.
    18. This is an open-access article distributed under the terms of the Creative Commons Attribution Non Commercial License, which permits noncommercial use, distribution, and reproduction in other forums, provided the original authors and source are credited.
    19. (2011). Thyroid hormones affect plasma ghrelin and obestatin levels.

    To submit an update or takedown request for this paper, please submit an Update/Correction/Removal Request.